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As seen in Figure 4B, the PEO-CS-LEV/PLGA and PEO-CS/PLGA-QS core-shell nanofibers demonstrate a burst release of 25% LEV and 16% QS in PBS within 2 h, followed by a sustained drug release over the next hours (up to 168th h)

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Inhibition of IGF-1 with the antagonist IGFBP-4 blunted fluid-flow stress-induced proliferation in the osteoblastic cell line MC3T3-E1 (Kesavan et al., 2011)