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A study on the intestinal microbiome of young and old mice has revealed that the gut microbial-derived metabolite 3-hydroxyphenylacetic acid upregulates GPX4 expression, inhibits ferroptosis, and alleviates spermatogenic dysfunction in aging mice [108]
Evaluation of histological scoring systems for tissue-engineered, repaired and osteoarthritic cartilage
The major ferroptosis-related pathways influenced by polysaccharides are the SLC7A11/GSH/GPX4 pathway, Keap1/Nrf2/HO-1 pathway, NCOA4-mediated ferritinophagy pathway, ACSL4-mediated lipid peroxidation pathway, and their upstream signal such as PI3K/Akt, Wnt/-catenin, p53, and the AMPK/BECN1 autophagy pathway
Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimers disease
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