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While not everyone with IgG4-RD experiences headaches, the disease can impact areas that lead to persistent or severe headaches, such as: The meninges: These protective brain layers can thicken and become inflamed (hypertrophic pachymeningitis), resulting in ongoing, sometimes debilitating headaches

Oral supplements and food undergo a time-consuming digestive breakdown, gut absorption, and first-pass metabolism, all of which slow the process down