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We further explore the translational potential of microbiota-targeted therapies, including probiotics, fecal microbiota transplantation, dietary interventions, and small-molecule modulators

View Protocol Complete dosage protocol and reconstitution guide for Thymosin Alpha-1 (10 mg Vial)

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Biochim Biophys Acta 1758:14611474

Lactate inhibits 2-oxoglutarate-dependent prolyl hydroxylases (PHDs) (mainly PHD2), which in turn prevents Von Hippel Lindau tumor suppressor (VHL)-mediated ubiquitination of hypoxia-inducible factor 1 (HIF-1) and its proteasomal degradation, thus stabilizing HIF-1