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To avoid metHb accumulation, reducing pathways mediated by cytochrome b5 or flavin coupled with NADH- or NADPH-dependent metHb reductases (MHbR), respectively, keep the level of metHb in erythrocytes at less than 1% of the total Hb under normal conditions (48)

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But chelations efficacy for CVD has been questioned for just as long

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and his team also found that 39-61% of the Chinese population had daily Se intakes below standards according to WHO/FAO recommendations