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Systemic water retention (48 pounds within first week) and hypoglycemic episodes (glucose drops to 5060mg/dL mid-training) occur in 3542% of users

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The histone methyltransferase NSD1 has been identified as having potential therapeutic value by upregulating the H3K36me2 modification, thereby activating the expression of the transcription factor SOX9, which subsequently downregulates the key enzyme for ferroptosis, ACSL4, thus attenuating chondrocyte ferroptosis (170)