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In general, these hypotheses present the assumption that microbiota of proper composition regulates epithelial barrier function, including by regulating barrier permeability and TJ, influencing vascular permeability and angiogenesis, and affecting local inflammation and GALT tolerance [1, 55, 56]

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The other points of generation of ROS are the cytoplasmic NADPH-oxidase, cytochrome p450 enzymes and the xanthine oxidoreductase enzymes