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Also, melanogenic switching was found to be related to tyrosinase activity levels, where high tyrosinase activity produced an excess of dopaquinone resulting in the inactivation of GR and other enzymes essential for pheomelanogenesis [99]

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This genetic metabolic block severely impairs the body's ability to produce cellular energy and clear out neurotoxins, directly contributing to the hallmark symptoms of ME/CFS, including profound post-exertional malaise (PEM) and unrefreshing sleep