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To compare simulated concentration time-courses with measured time-course data, we include the unknown concentration scale of fluorescence microscopy measurements and possible background fluorescence into an observation function

But for low-carb athletes, the calculus changes: Glycogen replenishment: If you're training moderately (not depleting sessions) and eating low-carb consistently, your body adapts to function on lower glycogen levels

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doi: 10.1016/0022-4731(84)90332-7