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Conventional methods like IV administration, liposomal delivery, and nasal sprays have proven ineffective for long-term optimization

Tian J, Li X, Jiang Y, Gao F, Ju B, Chen J et al (2022) SLC7A5 expression is up-regulated in peripheral blood T and B lymphocytes of systemic lupus erythematosus patients, associating with renal damage

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Nevertheless, if such formulations can demonstrably enhance exposure two- to three-fold, reduce dosing frequency, or minimize adverse effects relative to standard therapy, they may ultimately prove cost-effective by lowering reliance on multiple drugs and reducing downstream healthcare costs

Satisfaction with DOACs was high and did not differ between the groups (ACTS 70.7 5.5 vs 69.7 7.0, p = 0.23)