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People at Risk of Vitamin B12 Deficiency Due to vitamin B12 requiring the protein "intrinsic factor" to be effectively used for the body, certain people are at higher risk of vitamin B12 deficiency than the general population

PubMed Goldstein, A.L., Hannappel, E., & Kleinman, H.K

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But also, the opposite way is conceivable: if there is a lack of biotin, vitamin B12 cannot fulfil its function in the citrate cycle and remains unused in the tissue possibly leading to the behavioural change of the skin bacteria already discussed