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Glutaredoxins Glutaredoxins (Grx) are the glutathione-dependent enzymes that catalyze the inter-conversion of soluble thiols and disulfides (trans-sulfuration) and the transfer of glutathione, cysteine, homocysteine and cysteamine groups to protein cysteines and from thiolated cysteines, as part of the biological control mechanisms

Despite its translational advantages, clinical application of DFP and other iron chelators is not without risks: neutropenia remains a serious adverse event frequently observed in patients receiving iron chelation therapy (230)

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These are essential risk factors, but they do not tell the entire biological story