Decreased expression of apoptotic Markers, including caspase 3 and caspase 9, along with reduced rates of GC apoptosis in vitro and in vivo, following exosome treatment, supports this observation
J Sex Med 14(12):15751584 Cully M, You H, Levine AJ, Mak TW (2006) Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis
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Importantly, since both glutamate export and cysteine import via system XcT are tightly linked to ferroptosis regulation, changes in glutamate or cysteine availability resulting from altered 5-OP metabolism could significantly impact cellular susceptibility to oxidative stress (Figure 3E)
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