25, 38 As aberrations in the TP53 gene and t(4:14) translocations are seen in 15% of patients 49 and correlated with short progression-free survival and resistance to alkylating agents at relapse, 50 the ability of BSO to sensitize MM cells with this phenotype suggests that BSO+L-PAM may have clinical activity in the most aggressive forms of MM
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Furthermore, we assessed the role of GpoA in conferring resistance to oxidative stress, its involvement in ROS detoxification, its influence on bacterial survival within host cells, and its contribution to persistence during fluoroquinolone treatment
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