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The evidence base for tirzepatide as monotherapy is robust, with pivotal trials including SURMOUNT-1 demonstrating significant weight reduction in adults with obesity, and SURPASS trials establishing glycemic efficacy in type 2 diabetes

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However, after 14 days, SFN significantly increased the level of Bacteroidetes and decreased the level of Firmicutes changed by dextran sodium sulfate in mice with ulcerative colitis (Zhang et al., 2020)