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These numbers are unprecedented for a non-surgical, pharmacological intervention and notably the weight-loss curve had not fully plateaued at 48 weeks, suggesting that even greater reductions might occur with longer exposure

Influence of insulin-like growth factor I on nerve regeneration using allografts: a sciatic nerve model

Those are high-consequence conditions

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A study, in adult rats, showed that ICV infusion of BDNF induced the generation of new neurons as well as enhancing their survival in the RMS and the OB [40]