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Development and inter-rater reliability of the Liverpool adverse drug reaction causality assessment tool

These findings support a personalised approach, where absorption efficiency may be more relevant than absolute dosage

It was developed through structural modification of the native -MSH sequence to enhance receptor binding affinity and metabolic stability

R 3 is C 2 -C 6 alkyl, C 2 -C 6 alkenyl, C 1 -C 4 haloalkyl, optionally substituted C 3 -C 6 cycloalkyl, optionally substituted C 2 -C 7 heterocycloalkyl, optionally substituted C 6 -C 10 aryl, OR 6 , NR 5 R 6 , C(O)R 7 , CO 2 R 6 , C(O)NR 5 R 6 , N(R 5 )C(O)R 7 , N(R 5 )CO 2 R 7 , NHS(O) 2 R 7 , S(O) 2 NR 5 R 6 , or R 2 and R 3 together form an optionally substituted C 2 -C 7 heterocycloalkyl ring

This dosage is designed for optimal absorption and efficacy