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Ketogenic Diet The ketogenic diet is a high-fat, adequate-protein, very low-carbohydrate diet that shifts metabolism toward ketone production: Originally developed for epilepsy treatment, which is more common in ASD Some small studies suggest potential benefits for certain behaviors in ASD Proposed mechanisms include effects on mitochondrial function, inflammation, and neurotransmitter systems Research on the ketogenic diet for ASD is preliminary, with most studies being small case series or open-label trials

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Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation