It is not a drug or supplement and has not been evaluated by the FDA
238,242 Isocitrate dehydrogenase 3 (IDH3), a pivotal rate-limiting enzyme in the TCA cycle, is downregulated, leading to oxidative phosphorylation uncoupling and lactate accumulation in the brains of AD patients and AD transgenic mice
Additionally, it downregulated the expression of ionized calcium-binding adapter molecule 1 (Iba-1), inhibited spinal cord ferroptosis and inflammatory responses, and improved gait abnormalities and limb weakness in EAE mice
Thus, developing novel iron chelators, particularly nanoscale formulations, may represent a future direction to reduce side effects while maintaining or enhancing therapeutic efficacy (Kalanaky et al., 2016)

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