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This implies that the active metabolites may not be ideal drugs due to their fast clearance

For multi-draw research protocols, BAC water is the correct choice

I would consider 500-1000 mcg a maintenance dose, and 1-5 mg a therapeutic dose

The published research record is extensive for an unapproved compound hundreds of indexed animal studies, consistently favorable for treated groups across tendon, gut, and nervous-system injury models but the human evidence is thin: three small pilot studies, none controlled