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In the SURMOUNT-1 trial, tirzepatide produced average weight loss of 15-22.5% of body weight over 72 weeks depending on dose

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Furthermore, in bladder cancer, SHMT1 enhances the proliferation, invasion, and epithelial-mesenchymal transition (EMT) of cancer cells while suppressing apoptosis by promoting ATIC and inhibiting the AKT/FOXO3A signaling pathway, collectively driving malignant progression [112]

15 (2021): 698240 Coffin, ST, et al