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Adding to the confusion, a large study found that actual glutamate levels were elevated in adults: A meta-analysis of 1H-MRS studies from 1980 to 2010 on brain glutamate and glutamine in BD showed that patients with BD had widespread increased Glx, including in the prefrontal cortex

A major theme was that eligibility requirements for clinical trials are too narrowwhich means that less people have the chance to benefit and trials dont progress as quickly

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