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In vitro cultures of cisplatin-treated GCs to which metformin was added have displayed a significant reduction in the expression of senescence markers (p21, p16, and NF-B) and senescence-associated secretory phenotype (SASP) markers, IL-6 and IL-1, and in a number of senescence-associated beta-galactosidase (SA-gal)-staining cells, and ultimately, improved functional and structural changes occurred in cisplatin-induced POF mice (Lin et al., 2022)

Adv Drug Deliv Rev (2022) 185:114296