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For peptide research, that means faster degradation and higher contamination risk

Nevertheless, supplementation with 2 mg/d folic acid, 25 mg/d vitamin B6, and 400 g/d B12 during 6 months significantly decreased the homocysteine levels, severity, and disability of migraine attacks (60)

If the deficiency is detected, metformin can be continued while the deficiency is corrected with B 12 supplements

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This is likely to be important in diseases beyond type 2 diabetes where metformin is used chronically