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TSNAs rank among the most hazardous chemicals in tobacco smoke, along with nicotine, carbon monoxide, formaldehyde, and benzene

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Yet both proponents and opponents of legalization have overlooked the role of nicotine in leading to the use of illicit drugs and to addiction. The article is titled, A Molecular Basis for Nicotine as a Gateway Drug. The study was supported by grants from the Howard Hughes Medical Institute and the National Institutes of Health (R01 DA024001) and the National Institute on Drug Abuse (K5 DA00081)