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Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects

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Thus, extended interval strategies are an area of interest but not yet well validated

Mechanisms of Collagen Synthesis The collagen synthesis mechanisms involve several key pathways: MAPK/ERK Pathway Activation This pathway upregulates collagen gene expression and promotes fibroblast proliferation, creating the cellular foundation for tissue repair

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