Living in a high-performance culture can lead to chronic stress, which negatively impacts mental health and can contribute to unhealthy eating habits
It has been demonstrated that the cAMP response element regulator (CREM) could induce the ICER isoform to promote Th17-cell differentiation, which also enhanced the expression of GLS1, the first enzyme in the Gln catabolic pathway, so that inhibition of GLS1 could improve Th17 differentiation in vitro and in mouse EAE (47)
Hence, the microclots may result in decreased circulation and blockage of the microcapillaries, resulting in ischemia and therefore many symptoms of ME/CFS, as seen in Figure 9
6, pp.522-528 [online] Available at: Bozack, A.K., Howe, C.G., Hall, M.N., Liu, X., Slavkovich, V., Llievski, V., Lomax-Luu, A.M., Parvez, F., Siddique, A.B., Shahriar, H., Uddin, M.N., Islam, T., Graziano, J.H
Swelling that reaches beyond the injection site