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This approach requires twice the syringe preparation but may dramatically improve tolerability for patients who experience a predictable pattern of post-injection nausea followed by waning effect before the next dose

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Excess glucocorticoid exposure suppresses GH secretion mainly through the increase in hypothalamic somatostatin tone, whereas low cortisol levels causes relative GHD that is reversible by glucocorticoid therapy (Giustinas effect) ( Figure 5 ) (104)

Any medical safety advice will depend on a persons needs and medical history