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Tobacco substitute sheet (TSS) The TSS was made from calcium carbonate, bound with sodium alginate, loaded with glycerol (approximately 12.5%) and coloured with caramel

These chemical induce high levels of oxidative stress in smokers (7), and trigger and augment lipid peroxidation, which causes low-density lipoprotein (LDL) oxidation and atherosclerosis (9)

Night blood pressure and cigarette smoking: disparate association in healthy subjects and diabeticpatients Blood Press 1994 3 : 381388 Tachmes L, Fernandez RJ, Sackner MA

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