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Conclusion: The co-designed MSU pathway provides a foundation for MSU implementation in the NHS and can be subjected to local and regional modifications required for implementation

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No significant metabolic contraindications: Active malignancy, uncontrolled insulin resistance, or significant thyroid disease can alter both the risk-benefit calculation and the expected response

Weight loss, whether achieved through lifestyle changes like diet and exercise or medical interventions, can have significant effects on your menstrual cycle