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Brown Norway rats that did not undergo any treatment (PQ or eye drops) were also included as a healthy untreated control group

PLoS Negl Trop Dis 4:e601

The results of this study indicated that the prepared arbutin nanocomplex was accompanied by lower intracellular and extracellular melanin production, higher anti-inflammatory effects, and reduced toxicity potential in comparison to the free drug (Jimnez-Prez et al., 2018

Int J Rheum Dis

Moreover, the specific increase in the levels of IFN- and IL-2 related to thymic peptides suggests a targeted enhancement of Th1 immune responses, which are crucial for antiviral defense