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Several small molecule receptor kinase inhibitors have been developed for this purpose and are currently in clinical trials [337,338,339,340,341,342]

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Inflammatory back pain is a clinical diagnosis based on a history of back pain of insidious onset before the age of 40 to 45 years, pain with stiffness that improves with exercise, pain that is not relieved with rest, and pain that has been present for at least 3 months

This suggested that PAC may be a novel drug that inhibits ferroptosis (Zhou H