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Brain 139 , 14821496 (2016)

378 On the basis of the increased activity of -gal in senescent cells, a new prodrug, SSK1, which can be specifically cleaved by lysosomal -gal into cytotoxic substances and induce the apoptosis of senescent cells, thereby eliminating senescent cells, was developed

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Additionally, pro-inflammatory cytokines such as TNF-, IL-1, and IFN- boost ROS production via mitochondrial and nicotinamide adenine dinucleotide phosphate oxidase pathways [68, 69]