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31,32 A two year randomized clinical trial investigating the effect of a high dose of 100,000 International units (IU) (equivalent to 3,333 IU/day) versus the standard treatment 12,000 IU (equivalent to 400 IU/day) of oral vitamin D3 supplements for reducing risk of respiratory infections, was studied in 62 children and adolescents with SCD, aged 3-20 years
Cytokines mainly produced by immune cells, are the most dynamic components of the immune microenvironment and mediate cell-to-cell interactions
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Phosphorylation at Y239/Y240 site enhances STAT3-driven immunosuppressive pathways (e.g., PD-L1 expression) while repressing STAT1-mediated immune surveillance, reducing CD8+T cell infiltration 43
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