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Aluminium ions can lead to the accumulation of A and hyperphosphorylation of Tau proteins, resulting in neuronal death in the brain

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Structurally, the BBB is highly lipophilic and composed of cerebrovascular endothelial cells, astrocytes, pericytes, neuronal cells, immune cells, microglial cells, glial cells, smooth muscle cells, and a basement membrane (Fig

So this is the whole basis, most of the basis, behind how chemotherapeutic drugs work