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While RCTs remain the gold standard for intervention assessment, observational studies provide complementary evidence, especially when using objective biomarkers such as serum Vitamin B12, MMA, and homocysteine

Glutamine can reprogram the transcriptomic and proteomic programs in kidney tubular epithelial cells, reducing epithelial apoptosis

It allows a slow-release layer on the skin and supports barrier function

Frequently examined in cellular signaling and structural protein research models

Firstly, gallstone compositions were not available in the NHANES data, so the role of OBS in gallstones with different compositions is not clear