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Further, targeted metabolomics and isotope tracing experiments uncovered GGCT as a metabolic orchestrator to prioritize Gln to GSH flux for antioxidant defense, while activating glucose (Glc)-fueled anaplerosis to replenish TCA intermediates to fuel proliferation

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Notably, the effect of CR and DL feeding on Cysteine and Methionine metabolism was observed in both plasma and brain samples of female, but not male, 3xTg mice, with similar effects on most of the metabolites detected despite the pathway being upregulated in the brain and downregulated in the plasma (Fig

Fe SODs are most abundantly localized inside plant chloroplasts, where they are indigenous