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These effects usually resolve within a few hours to a few days

Be cautious with temperature changes

[1] [6] Severe deficiencies may include symptoms of reduced heart function, suppression of bone marrow, as well as more various severe neurological symptoms possibly including sensory loss, abnormal balance and reflexes, memory and consciousness impairment, smell and taste problems, depression, irritability, confusion, and psychosis

Associated with elevated NAD+ levels and SIRT1 activation in preclinical studies

In addition, high blood glucose itself may have an adverse impact by altering neurotransmitter and autonomic functions [1]