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For CNS-targeted research specifically, topical delivery remains largely impractical because the compound must still reach the brain after crossing the skina double barrier problem

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N -Glycosylation is required for Na + -dependent vitamin C transporter functionality

El pptido comienza intacto pero enfrenta mltiples obstculos: el cido estomacal acta como lluvia corrosiva, las enzimas digestivas funcionan como vientos fuertes tratando de desgarrarlo, y la barrera intestinal funciona como un filtro selectivo