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Reduced butyrate levels in CFS/ME patients may contribute to increased gut permeability (leaky gut), allowing microbial products like LPS to enter the circulation and trigger systemic immune activation (Wang J.-H

and has provided valuable insight into this interaction [43]

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J Mol Cell Cardiol 33:8394 Lee YW, Eum SY, Nath A, Toborek M (2004) Estrogen-mediated protection against HIV tat protein-induced inflammatory pathways in human vascular endothelial cells

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