While oral glutathione bioavailability has historically been debated, liposomal and acetylated forms improve uptake
For example, a compound may exhibit high antioxidant capacity in ORAC but be rendered ineffective in vivo due to poor absorption, rapid metabolism, or inability to reach the target site (Niki, 2010)
Consequently, failure to convert RanGTP to RanGDP, for example, due to RanGAP depletion, is predicted to result in an accumulation of RanGTP in the cytoplasm and a shift in the ratio of nuclear to cytoplasmic total Ran protein [38]
10.1111/tpj.15912 53 ItohK.NakamuraK.IijimaM.SesakiH
Rare but Serious Side Effects Although uncommon, some people may experience more severe side effects, especially if the glutathione are not administered properly or are of poor quality: Stevens-Johnson Syndrome: A rare but serious disorder of the skin and mucous membranes, potentially life-threatening if not treated promptly