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Suzuki J, Jin Z-G, Meoli DF, Matoba T, Berk BC

39 Many physiological processes require iron, but iron overload produces toxic effects because excessive free iron can easily change between trivalent and bivalent forms

Iron In 2008, Lemasters and colleagues recognized that an increase in chelatable iron in hepatocytes during severe oxidant stress induced by tert-butyl hydroperoxide originated from lysosomes