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In addition, high level of LDL-C can cause ectopic lipid deposition and associated metabolic diseases, such as non-alcoholic fatty liver disease ( Gut microbiota regulates several diseases, including liver diseases ( Microbial effects on cholesterol metabolism Gut microbiota, which is influenced by diet and living environment, is individually unique and highly related to cholesterol metabolism ( The SCFAs, BAs, TMAO, and LPS are major gut microbiota metabolites that broadly affect the human cholesterol metabolism