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Although incremental Medicare expenditures peak in the year after diagnosis and decrease in the subsequent four years, outofpocket costs have been shown to increase over time, from $3,104 in the first two years after diagnosis to $3,730 in years three to four after diagnosis, to $3,934 in years seven to eight after diagnosis (in 2017 dollars

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Early improvements may include reduced discomfort and better digestion, while deeper structural repair develops over several weeks of consistent use