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Acrolein and cigarette smoke were also demonstrated to upregulate MMP-1 expression and downregulate TIMP-3 expression in rabbit aortic endothelial cells, which was attributed to the inhibition of the mammalian target of rapamycinp70S6K pathway

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As a result, the plan generally excludes, as experimental, a treatment or procedure when no professionally recognized treatment guidelines include the treatment or procedure as a clinically appropriate standard of care for the condition or disorder and fewer than two randomized controlled trials are available to support the treatment's use with respect to the given condition or disorder