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Kishimoto A, Imaizumi A, Wada H, Yamakage H, Satoh-Asahara N, Hashimoto T, et al

In a two-step procedure, 2-hydroxymalondialdehyde is firstly condensed with p -aminobenzoyl-L-glutamic acid, forming a diimine, which subsequently reacts with triamino-pyrimidinone to obtain folic acid

doi: 10.1093/ajcn/32.7.1534 204 StacpoolePHarwoodHVarnadoC

The quality of log-linear regression and, consequently, the reliability of the extrapolated pharmacokinetic parameters (namely z , t , AUC 0 , AUC extra , V z , CL r and CL t ) was demonstrated by a determination coefficient, R 2 0.8