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In reality, the difference is primarily one of scientific terminology versus common usage

We aim to provide information about possible alternatives to drug treatments used alone or combined to reduce drug intake and encourage the consumption of natural ingredients at doses adequate to promote health and combat pathologies while reducing unwanted risks and side effects

PLoS ONE 8 , e82149 (2013)

As it stands, Epitalons pharmacological profile is promising but incomplete, raising key questions about long-term safety, optimal dosing, and how to harness its effects in a reliable, standardized way

It can also be oxidised into an inactive form unless it is manufactured with an enteric-coating or the SAMe itself is microencapsulated