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Loss-of-function mutations in the BCKDK gene are associated with a phenotype that is characterized by persistently reduced levels of BCAA in body fluids, developmental delay, microcephaly, and neurobehavioral abnormalities

What they do not have is a body of controlled evidence showing that injecting them causes clinically significant weight loss independent of diet, exercise, and the rest of a supervised program

doi: 10.1073/pnas.0610282104

The 2023 Category 2 listing told compounding pharmacies they could no longer prepare them

Goldman JG, Holden S (2014) Treatment of psychosis and dementia in Parkinsons disease