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7 CairnsP.EstellerM.HermanJ

Other possible mechanisms include the accumulation of Fas(Nam et al., 2007), downregulation of cyclooxygenase-2 (COX-2), and caspase-3 activation (Liu et al., 2007)

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The reduced activity of antioxidant enzymes in the body results in DNA hydroxylation, protein denaturation, increased lipid peroxidation, and impairment of cellular functions, disrupting the conditions necessary for cell survival