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Murine desnutrin/ATGL is found predominantly in adipose tissue, but it is also found at much lower levels in other tissues, notably cardiac and skeletal muscle and testis

Muscle tissue can also hold a larger volume of medication than subcutaneous tissue

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What is supported in animal models Increased lipolysis, increased fat oxidation, decreased lipogenesis, no apparent effect on plasma glucose or insulin sensitivity, and signal that intact beta-3 adrenergic receptor activity matters for the fat-loss effect

R., et al